Ontology highlight
ABSTRACT:
SUBMITTER: Perkins A
PROVIDER: S-EPMC5241139 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Perkins Arden A Parsonage Derek D Nelson Kimberly J KJ Ogba O Maduka OM Cheong Paul Ha-Yeon PH Poole Leslie B LB Karplus P Andrew PA
Structure (London, England : 1993) 20160901 10
Peroxiredoxins (Prxs) are ubiquitous cysteine-based peroxidases that guard cells against oxidative damage, are virulence factors for pathogens, and are involved in eukaryotic redox regulatory pathways. We have analyzed catalytically active crystals to capture atomic resolution snapshots of a PrxQ subfamily enzyme (from Xanthomonas campestris) proceeding through thiolate, sulfenate, and sulfinate species. These analyses provide structures of unprecedented accuracy for seeding theoretical studies, ...[more]