Protein kinase C ? signaling is required for dietary prebiotic-induced strengthening of intestinal epithelial barrier function.
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ABSTRACT:
SUBMITTER: Wu RY
PROVIDER: S-EPMC5241689 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Protein kinase C δ signaling is required for dietary prebiotic-induced strengthening of intestinal epithelial barrier function.
Wu Richard Y RY Abdullah Majd M Määttänen Pekka P Pilar Ana Victoria C AV Scruten Erin E Johnson-Henry Kathene C KC Napper Scott S O'Brien Catherine C Jones Nicola L NL Sherman Philip M PM
Scientific reports 20170118
Prebiotics are non-digestible oligosaccharides that promote the growth of beneficial gut microbes, but it is unclear whether they also have direct effects on the intestinal mucosal barrier. Here we demonstrate two commercial prebiotics, inulin and short-chain fructo-oligosaccharide (scFOS), when applied onto intestinal epithelia in the absence of microbes, directly promote barrier integrity to prevent pathogen-induced barrier disruptions. We further show that these effects involve the induction ...[more]
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