Centrality in the host-pathogen interactome is associated with pathogen fitness during infection.
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ABSTRACT:
SUBMITTER: Crua Asensio N
PROVIDER: S-EPMC5241799 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Centrality in the host-pathogen interactome is associated with pathogen fitness during infection.
Crua Asensio Núria N Muñoz Giner Elisabet E de Groot Natalia Sánchez NS Torrent Burgas Marc M
Nature communications 20170116
To perform their functions proteins must interact with each other, but how these interactions influence bacterial infection remains elusive. Here we demonstrate that connectivity in the host-pathogen interactome is directly related to pathogen fitness during infection. Using Y. pestis as a model organism, we show that the centrality-lethality rule holds for pathogen fitness during infection but only when the host-pathogen interactome is considered. Our results suggest that the importance of path ...[more]
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