Ontology highlight
ABSTRACT:
SUBMITTER: Backhed F
PROVIDER: S-EPMC524219 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Bäckhed Fredrik F Ding Hao H Wang Ting T Hooper Lora V LV Koh Gou Young GY Nagy Andras A Semenkovich Clay F CF Gordon Jeffrey I JI
Proceedings of the National Academy of Sciences of the United States of America 20041025 44
New therapeutic targets for noncognitive reductions in energy intake, absorption, or storage are crucial given the worldwide epidemic of obesity. The gut microbial community (microbiota) is essential for processing dietary polysaccharides. We found that conventionalization of adult germ-free (GF) C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despi ...[more]