Ontology highlight
ABSTRACT:
SUBMITTER: Shu C
PROVIDER: S-EPMC5242207 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Shu Cindy C Smith Susan M SM Little Christopher B CB Melrose James J
Future science OA 20160922 4
<h4>Aim</h4>Intervertebral disc degeneration/low back pain is the number one global musculoskeletal condition in terms of disability and socioeconomic impact.<h4>Materials & methods</h4>Multipotent mesenchymal stem cells (MSCs) were cultured in micromass pellets ± FGF-2 or -18 up to 41 days, matrix components were immunolocalized and gene expression monitored by quantitative-reverse transcription PCR.<h4>Results</h4>Chondrogenesis occurred earlier in FGF-18 than FGF-2 cultures. Lower <i>COL2A1, ...[more]