Ontology highlight
ABSTRACT:
SUBMITTER: Wang D
PROVIDER: S-EPMC5242300 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Wang Dan D Hou Lei L Nakamura Shuhei S Su Ming M Li Fang F Chen Weiyang W Yan Yizhen Y Green Christopher D CD Chen Di D Zhang Hong H Antebi Adam A Han Jing-Dong J JJ
Aging cell 20161011 1
The RNA-binding protein LIN-28 was first found to control developmental timing in Caenorhabditis elegans. Later, it was found to play important roles in pluripotency, metabolism, and cancer in mammals. Here we report that a low dosage of lin-28 enhanced stress tolerance and longevity, and reduced germline stem/progenitor cell number in C. elegans. The germline LIN-28-regulated microRNA let-7 was required for these effects by targeting akt-1/2 and decreasing their protein levels. AKT-1/2 and the ...[more]