Ontology highlight
ABSTRACT:
SUBMITTER: Papadopoulos C
PROVIDER: S-EPMC5242375 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Papadopoulos Chrisovalantis C Kirchner Philipp P Bug Monika M Grum Daniel D Koerver Lisa L Schulze Nina N Poehler Robert R Dressler Alina A Fengler Sven S Arhzaouy Khalid K Lux Vanda V Ehrmann Michael M Weihl Conrad C CC Meyer Hemmo H
The EMBO journal 20161017 2
Rupture of endosomes and lysosomes is a major cellular stress condition leading to cell death and degeneration. Here, we identified an essential role for the ubiquitin-directed AAA-ATPase, p97, in the clearance of damaged lysosomes by autophagy. Upon damage, p97 translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1, PLAA, and the deubiquitinating enzyme YOD1, which we term ELDR components for Endo-Lysosomal Damage Response. Together, they act downstream ...[more]