Death of Monocytes through Oxidative Burst of Macrophages and Neutrophils: Killing in Trans.

ABSTRACT: Monocytes and their descendants, macrophages, play a key role in the defence against pathogens. They also contribute to the pathogenesis of inflammatory diseases. Therefore, a mechanism maintaining a balance in the monocyte/macrophage population must be postulated. Our previous studies have shown that monocytes are impaired in DNA repair, rendering them vulnerable to genotoxic stress while monocyte-derived macrophages are DNA repair competent and genotoxic stress-resistant. Based on these findings, we hypothesized that monocytes can be selectively killed by reactive oxygen species (ROS) produced by activated macrophages. We also wished to know whether monocytes and macrophages are protected against their own ROS produced following activation. To this end, we studied the effect of the ROS b

SUBMITTER: Ponath V 

PROVIDER: S-EPMC5242493 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature