Ontology highlight
ABSTRACT:
SUBMITTER: Pruitt SC
PROVIDER: S-EPMC5242545 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Pruitt Steven C SC Qin Maochun M Wang Jianmin J Kunnev Dimiter D Freeland Amy A
PLoS genetics 20170103 1
Insufficient licensing of DNA replication origins has been shown to result in genome instability, stem cell deficiency, and cancers. However, it is unclear whether the DNA damage resulting from deficient replication licensing occurs generally or if specific sites are preferentially affected. To map locations of ongoing DNA damage in vivo, the DNAs present in red blood cell micronuclei were sequenced. Many micronuclei are the product of DNA breaks that leave acentromeric remnants that failed to s ...[more]