Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC524264 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Li Yonghong Y Nowotny Petra P Holmans Peter P Smemo Scott S Kauwe John S K JS Hinrichs Anthony L AL Tacey Kristina K Doil Lisa L van Luchene Ryan R Garcia Veronica V Rowland Charles C Schrodi Steve S Leong Diane D Gogic Goran G Chan Joanne J Cravchik Anibal A Ross David D Lau Kit K Kwok Shirley S Chang Sheng-Yung SY Catanese Joe J Sninsky John J White Thomas J TJ Hardy John J Powell John J Lovestone Simon S Morris John C JC Thal Leon L Owen Michael M Williams Julie J Goate Alison A Grupe Andrew A
Proceedings of the National Academy of Sciences of the United States of America 20041026 44
Although several genes have been implicated in the development of the early-onset autosomal dominant form of Alzheimer's disease (AD), the genetics of late-onset AD (LOAD) is complex. Loci on several chromosomes have been linked to the disease, but so far only the apolipoprotein E gene has been consistently shown to be a risk factor. We have performed a large-scale single-nucleotide polymorphism (SNP)-based association study, across the region of linkage on chromosome 12, in multiple case-contro ...[more]