Ontology highlight
ABSTRACT:
SUBMITTER: Schepelmann M
PROVIDER: S-EPMC5243220 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Schepelmann M M Yarova P L PL Lopez-Fernandez I I Davies T S TS Brennan S C SC Edwards P J PJ Aggarwal A A Graça J J Rietdorf K K Matchkov V V Fenton R A RA Chang W W Krssak M M Stewart A A Broadley K J KJ Ward D T DT Price S A SA Edwards D H DH Kemp P J PJ Riccardi D D
American journal of physiology. Cell physiology 20151104 3
The extracellular calcium-sensing receptor CaSR is expressed in blood vessels where its role is not completely understood. In this study, we tested the hypothesis that the CaSR expressed in vascular smooth muscle cells (VSMC) is directly involved in regulation of blood pressure and blood vessel tone. Mice with targeted CaSR gene ablation from vascular smooth muscle cells (VSMC) were generated by breeding exon 7 LoxP-CaSR mice with animals in which Cre recombinase is driven by a SM22α promoter (S ...[more]