Ontology highlight
ABSTRACT:
SUBMITTER: Li R
PROVIDER: S-EPMC5243269 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Li Ran R Hebert Jess D JD Lee Tara A TA Xing Hao H Boussommier-Calleja Alexandra A Hynes Richard O RO Lauffenburger Douglas A DA Kamm Roger D RD
Cancer research 20161121 2
The ability of a cancer cell to migrate through the dense extracellular matrix within and surrounding the solid tumor is a critical determinant of metastasis. Macrophages enhance invasion and metastasis in the tumor microenvironment, but the basis for their effects is not fully understood. Using a microfluidic 3D cell migration assay, we found that the presence of macrophages enhanced the speed and persistence of cancer cell migration through a 3D extracellular matrix in a matrix metalloproteina ...[more]