Biomarkers in anal cancer: from biological understanding to stratified treatment.
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ABSTRACT:
SUBMITTER: Jones CM
PROVIDER: S-EPMC5243987 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Biomarkers in anal cancer: from biological understanding to stratified treatment.
Jones Christopher M CM Goh Vicky V Sebag-Montefiore David D Gilbert Duncan C DC
British journal of cancer 20161206 2
Squamous cell carcinomas of the anus and anal canal represent a model of a cancer and perhaps the first where level 1 evidence supported primary chemoradiotherapy (CRT) in treating locoregional disease with curative intent. The majority of tumours are associated with infection with oncogenic subtypes of human papilloma virus and this plays a significant role in their sensitivity to treatment. However, not all tumours are cured with CRT and there remain opportunities to improve outcomes in terms ...[more]
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