Identification of mammalian microRNA host genes and transcription units.
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ABSTRACT:
SUBMITTER: Rodriguez A
PROVIDER: S-EPMC524413 | biostudies-literature | 2004 Oct
REPOSITORIES: biostudies-literature
Publications
Identification of mammalian microRNA host genes and transcription units.
Rodriguez Antony A Griffiths-Jones Sam S Ashurst Jennifer L JL Bradley Allan A
Genome research 20040913 10A
To derive a global perspective on the transcription of microRNAs (miRNAs) in mammals, we annotated the genomic position and context of this class of noncoding RNAs (ncRNAs) in the human and mouse genomes. Of the 232 known mammalian miRNAs, we found that 161 overlap with 123 defined transcription units (TUs). We identified miRNAs within introns of 90 protein-coding genes with a broad spectrum of molecular functions, and in both introns and exons of 66 mRNA-like noncoding RNAs (mlncRNAs). In addit ...[more]
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