Ontology highlight
ABSTRACT:
SUBMITTER: Guidi N
PROVIDER: S-EPMC5244470 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Guidi Novella N Geiger Hartmut H
Seminars in hematology 20161024 1
Until recently, there was broad consensus in the stem cell aging field that the phenotype of aged hematopoietic stem cells (HSCs) is fixed-dominated by cell-intrinsic regulatory mechanisms that cannot be altered by pharmacological or genetic means. The conventional thinking was that HSC aging could not be reverted by therapeutic intervention. This paradigm has started to shift dramatically, primarily because hallmarks of aged HSCs have been successfully reverted by distinct experimental approach ...[more]