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ABSTRACT: Objectives
To assess the extent and pattern of implementation of guidance issued by the National Institute for Clinical Excellence (NICE).Design
Interrupted time series analysis, review of case notes, survey, and interviews.Setting
Acute and primary care trusts in England and Wales.Participants
All primary care prescribing, hospital pharmacies; a random sample of 20 acute trusts, 17 mental health trusts, and 21 primary care trusts; and senior clinicians and managers from five acute trusts.Main outcome measures
Rates of prescribing and use of procedures and medical devices relative to evidence based guidance.Results
6308 usable patient audit forms were returned. Implementation of NICE guidance varied by trust and by topic. Prescribing of some taxanes for cancer (P < 0.002) and orlistat for obesity (P < 0.001) significantly increased in line with guidance. Prescribing of drugs for Alzheimer's disease and prophylactic extraction of wisdom teeth showed trends consistent with, but not obviously a consequence of, the guidance. Prescribing practice often did not accord with the details of the guidance. No change was apparent in the use of hearing aids, hip prostheses, implantable cardioverter defibrillators, laparoscopic hernia repair, and laparoscopic colorectal cancer surgery after NICE guidance had been issued.Conclusions
Implementation of NICE guidance has been variable. Guidance seems more likely to be adopted when there is strong professional support, a stable and convincing evidence base, and no increased or unfunded costs, in organisations that have established good systems for tracking guidance implementation and where the professionals involved are not isolated. Guidance needs to be clear and reflect the clinical context.
SUBMITTER: Sheldon TA
PROVIDER: S-EPMC524545 | biostudies-literature | 2004 Oct
REPOSITORIES: biostudies-literature
BMJ (Clinical research ed.) 20041001 7473
<h4>Objectives</h4>To assess the extent and pattern of implementation of guidance issued by the National Institute for Clinical Excellence (NICE).<h4>Design</h4>Interrupted time series analysis, review of case notes, survey, and interviews.<h4>Setting</h4>Acute and primary care trusts in England and Wales.<h4>Participants</h4>All primary care prescribing, hospital pharmacies; a random sample of 20 acute trusts, 17 mental health trusts, and 21 primary care trusts; and senior clinicians and manage ...[more]