Ontology highlight
ABSTRACT:
SUBMITTER: Mayers JR
PROVIDER: S-EPMC5245791 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Mayers Jared R JR Torrence Margaret E ME Danai Laura V LV Papagiannakopoulos Thales T Davidson Shawn M SM Bauer Matthew R MR Lau Allison N AN Ji Brian W BW Dixit Purushottam D PD Hosios Aaron M AM Muir Alexander A Chin Christopher R CR Freinkman Elizaveta E Jacks Tyler T Wolpin Brian M BM Vitkup Dennis D Vander Heiden Matthew G MG
Science (New York, N.Y.) 20160901 6304
Tumor genetics guides patient selection for many new therapies, and cell culture studies have demonstrated that specific mutations can promote metabolic phenotypes. However, whether tissue context defines cancer dependence on specific metabolic pathways is unknown. Kras activation and Trp53 deletion in the pancreas or the lung result in pancreatic ductal adenocarinoma (PDAC) or non-small cell lung carcinoma (NSCLC), respectively, but despite the same initiating events, these tumors use branched- ...[more]