A Pre-Clinical Safety Evaluation of SBP (HBsAg-Binding Protein) Adjuvant for Hepatitis B Vaccine.
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ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC5245819 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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A Pre-Clinical Safety Evaluation of SBP (HBsAg-Binding Protein) Adjuvant for Hepatitis B Vaccine.
Wang Jingbo J Su Caixia C Liu Rui R Liu Baoxiu B Khan Inam Ullah IU Xie Jun J Zhu Naishuo N
PloS one 20170119 1
Although adjuvants are a common component of many vaccines, there are few adjuvants licensed for use in humans due to concerns about their toxic effects. There is a need to develop new and safe adjuvants, because some existing vaccines have low immunogenicity among certain patient groups. In this study, SBP, a hepatitis B surface antigen binding protein that was discovered through screening a human liver cDNA expression library, was introduced into hepatitis B vaccine. A good laboratory practice ...[more]
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