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High risks of lung disease associated with early-life and moderate lifetime arsenic exposure in northern Chile.

ABSTRACT: Arsenic in drinking water has been associated with increases in lung disease, but information on the long-term impacts of early-life exposure or moderate exposure levels are limited.We investigated pulmonary disease and lung function in 795 subjects from three socio-demographically similar areas in northern Chile: Antofagasta, which had a well-described period of high arsenic water concentrations (860?g/L) from 1958 to 1970; Iquique, which had long-term arsenic water concentrations near 60?g/L; and Arica, with long-term water concentrations ?10?g/L.Compared to adults never exposed >10?g/L, adults born in Antofagasta during the high exposure period had elevated odds ratios (OR) of respiratory symptoms (e.g., OR for shortness of breath=5.56, 90% confidence interval (CI): 2.68-11.5), and decreases in pulmonary function (e.g., 224mL decrease in forced vital capacity in nonsmokers, 90% CI: 97-351mL). Subjects with long-term exposure to arsenic water concentrations near 60?g/L also had increases in some pulmonary symptoms and reduced lung function.Overall, these findings provide new evidence that in utero or childhood arsenic exposure is associated with non-malignant pulmonary disease in adults. They also provide preliminary new evidence that long-term exposures to moderate levels of arsenic may be associated with lung toxicity, although the magnitude of these latter findings were greater than expected and should be confirmed.

SUBMITTER: Steinmaus C

PROVIDER: S-EPMC5247272 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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High risks of lung disease associated with early-life and moderate lifetime arsenic exposure in northern Chile.

Steinmaus Craig C Ferreccio Catterina C Acevedo Johanna J Balmes John R JR Liaw Jane J Troncoso Patricia P Dauphiné David C DC Nardone Anthony A Smith Allan H AH

Toxicology and applied pharmacology 20161008

<h4>Background</h4>Arsenic in drinking water has been associated with increases in lung disease, but information on the long-term impacts of early-life exposure or moderate exposure levels are limited.<h4>Methods</h4>We investigated pulmonary disease and lung function in 795 subjects from three socio-demographically similar areas in northern Chile: Antofagasta, which had a well-described period of high arsenic water concentrations (860μg/L) from 1958 to 1970; Iquique, which had long-term arsenic ...[more]

PMID: 27725189

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Project description:IMPORTANCE:Rice-a typical first food and major ingredient in various infant foods-contains inorganic arsenic (As), but the extent of As exposure from these foods has not been well characterized in early childhood. OBJECTIVE:To determine the types and frequency of rice and rice-containing products consumed by infants in the first year of life and the association with As biomarker concentrations. DESIGN, SETTING, AND PARTICIPANTS:Included were infants from singleton births of pregnant women enrolled in the New Hampshire Birth Cohort Study from 2011 to 2014 whose parents were interviewed during their first year of life. Enrolled women from selected clinics were aged 18 to 45 years, living in the same residence since their last menstrual period, in households served by a private water system, and had no plans to move during pregnancy. Data on infants' intake of rice and rice products were collected from interviews with their parents at 4, 8, and 12 months' follow-up and from a 3-day food diary at 12 months from March 2013 to August 2014. EXPOSURES:Infants' intake of rice and rice products. MAIN OUTCOMES AND MEASURES:Total urinary As and the sum of As species measured using inductively coupled mass spectrometry and high-performance liquid chromatography with inductively coupled mass spectrometry. Commonly reported infant rice snacks were tested for As. RESULTS:We obtained dietary data on 759 of 951 infants (79.8% participation rate). Of these, 391 infants (51.7%) were male, and the mean (SD) gestational age was 39.4 (1.7) weeks. An estimated 80% were introduced to rice cereal during their first year. At 12 months, 32.6% of infants (42 of 129) were fed rice snacks. Among infants aged 12 months who did not eat fish or seafood, the geometric mean total urinary As concentrations were higher among those who ate infant rice cereal (9.53 µg/L) or rice snacks (4.97 µg/L) compared with those who did not eat rice or rice products (2.85 µg/L; all P?<?.01). Infant rice snacks contained between 36 and 568 ng/g of As and 5 to 201 ng/g of inorganic As. CONCLUSIONS AND RELEVANCE:Our findings indicate that intake of rice cereal and other rice-containing foods, such as rice snacks, contribute to infants' As exposure and suggest that efforts should be made to reduce As exposure during this critical phase of development.

Dataset Information

High risks of lung disease associated with early-life and moderate lifetime arsenic exposure in northern Chile.

Publications

High risks of lung disease associated with early-life and moderate lifetime arsenic exposure in northern Chile.

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