Marine ?-3 polyunsaturated fatty acid intake and survival after colorectal cancer diagnosis.

ABSTRACT: OBJECTIVE:Experimental evidence supports an antineoplastic activity of marine ?-3 polyunsaturated fatty acids (?-3 PUFAs; including eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid). However, the influence of ?-3 PUFAs on colorectal cancer (CRC) survival is unknown. DESIGN:Within the Nurses' Health Study and Health Professionals Follow-up Study, we prospectively studied CRC-specific and overall mortality in a cohort of 1659 patients with CRC according to intake of marine ?-3 PUFAs and its change after diagnosis. RESULTS:Higher intake of marine ?-3 PUFAs after CRC diagnosis was associated with lower risk of CRC-specific mortality (p for trend=0.03). Compared with patients who consumed <0.10?g/day of marine ?-3 PUFAs, those consuming at least 0.30?g/day had an adjusted HR for CRC-specific mortality of 0.59 (95% CI 0.35 to 1.01). Patients who increased their marine ?-3 PUFA intake by at least 0.15?g/day after diagnosis had an HR of 0.30 (95% CI 0.14 to 0.64, p for trend <0.001) for CRC deaths, compared with those who did not change or changed their intake by <0.02?g/day. No association was found between postdiagnostic marine ?-3 PUFA intake and all-cause mortality (p for trend=0.47). CONCLUSIONS:High marine ?-3 PUFA intake after CRC diagnosis is associated with lower risk of CRC-specific mortality. Increasing consumption of marine ?-3 PUFAs after diagnosis may confer additional benefits to patients with CRC.

SUBMITTER: Song M 

PROVIDER: S-EPMC5247396 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature