Ontology highlight
ABSTRACT:
SUBMITTER: Pinar A
PROVIDER: S-EPMC5247656 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Pinar Anita A Dowling Jennifer K JK Bitto Natalie J NJ Robertson Avril A B AA Latz Eicke E Stewart Cameron R CR Drummond Grant R GR Cooper Matthew A MA McAuley Julie L JL Tate Michelle D MD Mansell Ashley A
The Journal of biological chemistry 20161202 3
The emergence of avian H7N9 influenza A virus in humans with associated high mortality has highlighted the threat of a potential pandemic. Fatal H7N9 infections are characterized by hyperinflammation and increased cellular infiltrates in the lung. Currently there are limited therapies to address the pathologies associated with H7N9 infection and the virulence factors that contribute to these pathologies. We have found that PB1-F2 derived from H7N9 activates the NLRP3 inflammasome and induces lun ...[more]