Ontology highlight
ABSTRACT:
SUBMITTER: Deuis JR
PROVIDER: S-EPMC5247677 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20170120
Human genetic studies have implicated the voltage-gated sodium channel Na<sub>V</sub>1.7 as a therapeutic target for the treatment of pain. A novel peptide, μ-theraphotoxin-Pn3a, isolated from venom of the tarantula Pamphobeteus nigricolor, potently inhibits Na<sub>V</sub>1.7 (IC<sub>50</sub> 0.9 nM) with at least 40-1000-fold selectivity over all other Na<sub>V</sub> subtypes. Despite on-target activity in small-diameter dorsal root ganglia, spinal slices, and in a mouse model of pain induced b ...[more]