Effect of myocyte-fibroblast coupling on the onset of pathological dynamics in a model of ventricular tissue.

ABSTRACT: Managing lethal cardiac arrhythmias is one of the biggest challenges in modern cardiology, and hence it is very important to understand the factors underlying such arrhythmias. While early afterdepolarizations (EAD) of cardiac cells is known to be one such arrhythmogenic factor, the mechanisms underlying the emergence of tissue level arrhythmias from cellular level EADs is not fully understood. Another known arrhythmogenic condition is fibrosis of cardiac tissue that occurs both due to aging and in many types of heart diseases. In this paper we describe the results of a systematic in-silico study, using the TNNP model of human cardiac cells and MacCannell model for (myo)fibroblasts, on the possible effects of diffuse fibrosis on arrhythmias occurring via EADs. We find that depending on the

SUBMITTER: Sridhar S 

PROVIDER: S-EPMC5247688 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature