Ontology highlight
ABSTRACT:
SUBMITTER: Perrin-Cocon L
PROVIDER: S-EPMC5247753 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20170120
Dysregulated Toll-like receptor (TLR)-4 activation is involved in acute systemic sepsis, chronic inflammatory diseases, such as atherosclerosis and diabetes, and in viral infections, such as influenza infection. Thus, therapeutic control of the TLR4 signalling pathway is of major interest. Here we tested the activity of the small-molecule synthetic TLR4 antagonist, FP7, in vitro on human monocytes and monocyte-derived dendritic cells (DCs) and in vivo during influenza virus infection of mice. Ou ...[more]