Ontology highlight
ABSTRACT:
SUBMITTER: Koop G
PROVIDER: S-EPMC5247767 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Koop Gerrit G Vrieling Manouk M Storisteanu Daniel M L DM Lok Laurence S C LS Monie Tom T van Wigcheren Glenn G Raisen Claire C Ba Xiaoliang X Gleadall Nicholas N Hadjirin Nazreen N Timmerman Arjen J AJ Wagenaar Jaap A JA Klunder Heleen M HM Fitzgerald J Ross JR Zadoks Ruth R Paterson Gavin K GK Torres Carmen C Waller Andrew S AS Loeffler Anette A Loncaric Igor I Hoet Armando E AE Bergström Karin K De Martino Luisa L Pomba Constança C de Lencastre Hermínia H Ben Slama Karim K Gharsa Haythem H Richardson Emily J EJ Chilvers Edwin R ER de Haas Carla C van Kessel Kok K van Strijp Jos A G JA Harrison Ewan M EM Holmes Mark A MA
Scientific reports 20170120
Bicomponent pore-forming leukocidins are a family of potent toxins secreted by Staphylococcus aureus, which target white blood cells preferentially and consist of an S- and an F-component. The S-component recognizes a receptor on the host cell, enabling high-affinity binding to the cell surface, after which the toxins form a pore that penetrates the cell lipid bilayer. Until now, six different leukocidins have been described, some of which are host and cell specific. Here, we identify and charac ...[more]