Ontology highlight
ABSTRACT:
SUBMITTER: Jiang H
PROVIDER: S-EPMC5248620 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Jiang Hui H Zhang Chen C Tang Yu Y Zhao Juan J Wang Tan T Liu Heng H Sun Xiulian X
Journal of neurochemistry 20161220 2
The over-expression of regulator of calcineurin 1 isoform 1 (RCAN1.1) has been implicated in mitochondrial dysfunctions of Alzheimer's disease; however, the mechanism linking RCAN1.1 over-expression and the mitochondrial dysfunctions remains unknown. In this study, we use human neuroblastoma SH-SY5Y cells stably expressing RCAN1.1S and rat primary neurons infected with RCAN1.1S expression lentivirus to study the association of RCAN1 with mitochondrial functions. Our study here showed that the ov ...[more]