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Diastereomeric bactericidal effect of Ru(phenanthroline)2 dipyridophenazine.

ABSTRACT: Metal susceptibility assays and spot plating were used to investigate the antimicrobial activity of enantiopure [Ru(phen)2 dppz]2+ (phen =1,10-phenanthroline and dppz = dipyrido[3,2-a:2´,3´-c]phenazine) and [?-bidppz(phen)4 Ru2 ]4+ (bidppz =11,11´-bis(dipyrido[3,2-a:2´,3´-c]phenazinyl)), on Gram-negative Escherichia coli and Gram-positive Bacillus subtilis as bacterial models. The minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined for both complexes: while [?-bidppz(phen)4 Ru2 ]4+ only showed a bactericidal effect at the highest concentrations tested, the antimicrobial activity of [Ru(phen)2 dppz]2+ against B. subtilis was comparable to that of tetracyline. In addition, the ?-enantiomer of [Ru(phen)2 dppz]2+ showed a 2-fold higher bacteriostatic and bactericidal effect compared to the ?-enantiomer. This was in accordance with the enantiomers relative binding affinity for DNA, thus strongly indicating DNA binding as the mode of action.

SUBMITTER: Martensson AK 

PROVIDER: S-EPMC5248623 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Diastereomeric bactericidal effect of Ru(phenanthroline)<sub>2</sub> dipyridophenazine.

Mårtensson Anna K F AK   Bergentall Mattias M   Tremaroli Valentina V   Lincoln Per P  

Chirality 20161101 11

Metal susceptibility assays and spot plating were used to investigate the antimicrobial activity of enantiopure [Ru(phen)<sub>2</sub> dppz]<sup>2+</sup> (phen =1,10-phenanthroline and dppz = dipyrido[3,2-a:2´,3´-c]phenazine) and [μ-bidppz(phen)<sub>4</sub> Ru<sub>2</sub> ]<sup>4</sup><sup>+</sup> (bidppz =11,11´-bis(dipyrido[3,2-a:2´,3´-c]phenazinyl)), on Gram-negative Escherichia coli and Gram-positive Bacillus subtilis as bacterial models. The minimum inhibitory concentrations (MIC) and minimu  ...[more]

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