Ontology highlight
ABSTRACT:
SUBMITTER: Holterman L
PROVIDER: S-EPMC525025 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Holterman Lennart L Vogels Ronald R van der Vlugt Remko R Sieuwerts Martijn M Grimbergen Jos J Kaspers Jorn J Geelen Eric E van der Helm Esmeralda E Lemckert Angelique A Gillissen Gert G Verhaagh Sandra S Custers Jerome J Zuijdgeest David D Berkhout Ben B Bakker Margreet M Quax Paul P Goudsmit Jaap J Havenga Menzo M
Journal of virology 20041201 23
A novel plasmid-based adenovirus vector system that enables manufacturing of replication-incompetent (DeltaE1) adenovirus type 11 (Ad11)-based vectors is described. Ad11 vectors are produced on PER.C6/55K cells yielding high-titer vector batches after purification. Ad11 seroprevalence proves to be significantly lower than that of Ad5, and neutralizing antibody titers against Ad11 are low. Ad11 seroprevalence among human immunodeficiency virus-positive (HIV(+)) individuals is as low as that among ...[more]