Ontology highlight
ABSTRACT:
SUBMITTER: Yao L
PROVIDER: S-EPMC5253171 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Neural plasticity 20170109
The N-methyl-D-aspartate receptors (NMDARs) are subtype glutamate receptors that play important roles in excitatory neurotransmission and synaptic plasticity. Their hypo- or hyperactivation are proposed to contribute to the genesis or progression of various brain diseases, including stroke, schizophrenia, depression, and Alzheimer's disease. Past efforts in targeting NMDARs for therapeutic intervention have largely been on inhibitors of NMDARs. In light of the discovery of NMDAR hypofunction in ...[more]