MET: roles in epithelial-mesenchymal transition and cancer stemness.
Ontology highlight
ABSTRACT:
SUBMITTER: Jeon HM
PROVIDER: S-EPMC5253283 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
MET: roles in epithelial-mesenchymal transition and cancer stemness.
Annals of translational medicine 20170101 1
In a number of cancers, deregulated MET pathway leads to aberrantly activated proliferative and invasive signaling programs that promote malignant transformation, cell motility and migration, angiogenesis, survival in hypoxia, and invasion. A better understanding of oncogenic MET signaling will help us to discover effective therapeutic approaches and to identify which tumors are likely to respond to MET-targeted cancer therapy. In this review, we will summarize the roles of MET signaling in canc ...[more]
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