Ontology highlight
ABSTRACT:
SUBMITTER: Tagal V
PROVIDER: S-EPMC5253647 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Nature communications 20170119
Mutations in the SMARCA4/BRG1 gene resulting in complete loss of its protein (BRG1) occur frequently in non-small cell lung cancer (NSCLC) cells. Currently, no single therapeutic agent has been identified as synthetically lethal with SMARCA4/BRG1 loss. We identify AURKA activity as essential in NSCLC cells lacking SMARCA4/BRG1. In these cells, RNAi-mediated depletion or chemical inhibition of AURKA induces apoptosis and cell death in vitro and in xenograft mouse models. Disc large homologue-asso ...[more]