Ontology highlight
ABSTRACT:
SUBMITTER: Huang C
PROVIDER: S-EPMC5253665 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Huang Chongbiao C Li Na N Li Zengxun Z Chang Antao A Chen Yanan Y Zhao Tiansuo T Li Yang Y Wang Xiuchao X Zhang Wei W Wang Zhimin Z Luo Lin L Shi Jingjing J Yang Shengyu S Ren He H Hao Jihui J
Nature communications 20170119
Interleukin 35 (IL-35) is a novel member of the IL-12 family, consisting of an EBV-induced gene 3 (EBI3) subunit and a P35 subunit. IL-35 is an immune-suppressive cytokine mainly produced by regulatory T cells. However, the role of IL-35 in cancer metastasis and progression is not well understood. Here we demonstrate that IL-35 is overexpressed in human pancreatic ductal adenocarcinoma (PDAC) tissues, and that IL-35 overexpression is associated with poor prognosis in PDAC patients. IL-35 has cri ...[more]