Multi-omics analyses reveal metabolic alterations regulated by hepatitis B virus core protein in hepatocellular carcinoma cells.
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ABSTRACT:
SUBMITTER: Xie Q
PROVIDER: S-EPMC5253728 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Multi-omics analyses reveal metabolic alterations regulated by hepatitis B virus core protein in hepatocellular carcinoma cells.
Xie Qi Q Fan Fengxu F Wei Wei W Liu Yang Y Xu Zhongwei Z Zhai Linhui L Qi Yingzi Y Ye Bingyu B Zhang Yao Y Basu Sumit S Zhao Zhihu Z Wu Junzhu J Xu Ping P
Scientific reports 20170123
Chronic hepatitis B virus (HBV) infection is partly responsible for hepatitis, fatty liver disease and hepatocellular carcinoma (HCC). HBV core protein (HBc), encoded by the HBV genome, may play a significant role in HBV life cycle. However, the function of HBc in the occurrence and development of liver disease is still unclear. To investigate the underlying mechanisms, HBc-transfected HCC cells were characterized by multi-omics analyses. Combining proteomics and metabolomics analyses, our resul ...[more]
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