MYH9 binds to lncRNA gene PTCSC2 and regulates FOXE1 in the 9q22 thyroid cancer risk locus.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5255605 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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MYH9 binds to lncRNA gene PTCSC2 and regulates FOXE1 in the 9q22 thyroid cancer risk locus.
Wang Yanqiang Y He Huiling H Li Wei W Phay John J Shen Rulong R Yu Lianbo L Hancioglu Baris B de la Chapelle Albert A
Proceedings of the National Academy of Sciences of the United States of America 20170103 3
A locus on chromosome 9q22 harbors a SNP (rs965513) firmly associated with risk of papillary thyroid carcinoma (PTC). The locus also comprises the forkhead box E1 (FOXE1) gene, which is implicated in thyroid development, and a long noncoding RNA (lncRNA) gene, papillary thyroid cancer susceptibility candidate 2 (PTCSC2). How these might interact is not known. Here we report that PTCSC2 binds myosin-9 (MYH9). In a bidirectional promoter shared by FOXE1 and PTCSC2, MYH9 inhibits the promoter activ ...[more]
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