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Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation.

ABSTRACT: Cytomegalovirus displays genetic heterogeneity, which has implications for antiviral and vaccine development. Many studies have focused on laboratory isolates that have been extensively adapted for growth on fibroblasts. Here, we report whole-genome sequences for 10 human cytomegalovirus (HCMV) strains that readily grow on ARPE-19 human retinal pigment epithelial cells.

SUBMITTER: Corcoran K

PROVIDER: S-EPMC5255926 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature

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Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation.

Corcoran Kathleen K Sherrod Carly J CJ Perkowski Ellen F EF Texier Jordan J Li Fengsheng F Wang I-Ming IM McVoy Michael M Fu Tong-Ming TM Dittmer Dirk P DP

Genome announcements 20170119 3

Cytomegalovirus displays genetic heterogeneity, which has implications for antiviral and vaccine development. Many studies have focused on laboratory isolates that have been extensively adapted for growth on fibroblasts. Here, we report whole-genome sequences for 10 human cytomegalovirus (HCMV) strains that readily grow on ARPE-19 human retinal pigment epithelial cells. ...[more]

PMID: 28104650

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