Ontology highlight
ABSTRACT:
SUBMITTER: Garcez PP
PROVIDER: S-EPMC5256095 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Scientific reports 20170123
Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular consequences of ZIKV to human brain development are still not fully understood. Here we describe alterations in human neurospheres derived from induced pluripotent stem (iPS) cells infected with the strain of Zika virus that is circulating in Brazil. Combining proteomics and mRNA transcriptional profiling, over 500 proteins and genes associated with the Brazilian ZIKV infection were foun ...[more]