Ontology highlight
ABSTRACT:
SUBMITTER: Kuang R
PROVIDER: S-EPMC5256137 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Kuang Ruby R Jahangiri Arman A Mascharak Smita S Nguyen Alan A Chandra Ankush A Flanigan Patrick M PM Yagnik Garima G Wagner Jeffrey R JR De Lay Michael M Carrera Diego D Castro Brandyn A BA Hayes Josie J Sidorov Maxim M Garcia Jose Luiz Izquierdo JLI Eriksson Pia P Ronen Sabrina S Phillips Joanna J Molinaro Annette A Koliwad Suneil S Aghi Manish K MK
JCI insight 20170126 2
Clinical trials revealed limited response duration of glioblastomas to VEGF-neutralizing antibody bevacizumab. Thriving in the devascularized microenvironment occurring after antiangiogenic therapy requires tumor cell adaptation to decreased glucose, with 50% less glucose identified in bevacizumab-treated xenografts. Compared with bevacizumab-responsive xenograft cells, resistant cells exhibited increased glucose uptake, glycolysis, <sup>13</sup>C NMR pyruvate to lactate conversion, and survival ...[more]