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Recent Advances in Application of Pharmacogenomics for Biotherapeutics.

ABSTRACT: Biotherapeutics (BTs), one of the fastest growing classes of drug molecules, offer several advantages over the traditional small molecule pharmaceuticals because of their relatively high specificity, low off-target effects, and biocompatible metabolism, in addition to legal and logistic advantages. However, their clinical utility is limited, among other things, by their high immunogenic potential and/or variable therapeutic efficacy in different patient populations. Both of these issues, also commonly experienced with small molecule drugs, have been addressed effectively in a number of cases by the successful application of pharmacogenomic tools and approaches. In this introductory article of the special issue, we review the current state of application of pharmacogenomics to BTs and offer suggestions for further expansion of the field.

SUBMITTER: Mahajan PB

PROVIDER: S-EPMC5256619 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Recent Advances in Application of Pharmacogenomics for Biotherapeutics.

Mahajan Pramod B PB

The AAPS journal 20160323 3

Biotherapeutics (BTs), one of the fastest growing classes of drug molecules, offer several advantages over the traditional small molecule pharmaceuticals because of their relatively high specificity, low off-target effects, and biocompatible metabolism, in addition to legal and logistic advantages. However, their clinical utility is limited, among other things, by their high immunogenic potential and/or variable therapeutic efficacy in different patient populations. Both of these issues, also co ...[more]

PMID: 27007601

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