Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease.
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ABSTRACT:
SUBMITTER: Kastanenka KV
PROVIDER: S-EPMC5257003 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease.
Kastanenka Ksenia V KV Hou Steven S SS Shakerdge Naomi N Logan Robert R Feng Danielle D Wegmann Susanne S Chopra Vanita V Hawkes Jonathan M JM Chen Xiqun X Bacskai Brian J BJ
PloS one 20170123 1
Slow oscillations are important for consolidation of memory during sleep, and Alzheimer's disease (AD) patients experience memory disturbances. Thus, we examined slow oscillation activity in an animal model of AD. APP mice exhibit aberrant slow oscillation activity. Aberrant inhibitory activity within the cortical circuit was responsible for slow oscillation dysfunction, since topical application of GABA restored slow oscillations in APP mice. In addition, light activation of channelrhodopsin-2 ...[more]
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