Disrupting the Constitutive, Homodimeric Protein-Protein Interface in CK2? Using a Biophysical Fragment-Based Approach.
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ABSTRACT:
SUBMITTER: Seetoh WG
PROVIDER: S-EPMC5257173 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Disrupting the Constitutive, Homodimeric Protein-Protein Interface in CK2β Using a Biophysical Fragment-Based Approach.
Seetoh Wei-Guang WG Abell Chris C
Journal of the American Chemical Society 20161020 43
Identifying small molecules that induce the disruption of constitutive protein-protein interfaces is a challenging objective. Here, a targeted biophysical screening cascade was employed to specifically identify small molecules that could disrupt the constitutive, homodimeric protein-protein interface within CK2β. This approach could potentially be applied to achieve subunit disassembly of other homo-oligomeric proteins as a means of modulating protein function. ...[more]
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