Ontology highlight
ABSTRACT:
SUBMITTER: Luo X
PROVIDER: S-EPMC5258183 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Luo Xin X Ryu Keun Woo KW Kim Dae-Seok DS Nandu Tulip T Medina Carlos J CJ Gupte Rebecca R Gibson Bryan A BA Soccio Raymond E RE Yu Yonghao Y Gupta Rana K RK Kraus W Lee WL
Molecular cell 20170101 2
Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification of proteins mediated by PARP family members, such as PARP-1. Although PARylation has been studied extensively, few examples of definitive biological roles for site-specific PARylation have been reported. Here we show that C/EBPβ, a key pro-adipogenic transcription factor, is PARylated by PARP-1 on three amino acids in a conserved regulatory domain. PARylation at these sites inhibits C/EBPβ's DNA binding and transcriptional ...[more]