Ontology highlight
ABSTRACT: Conclusion
NAD availability is limiting during liver regeneration, and supplementation with precursors such as NR may be therapeutic in settings of acute liver injury. (Hepatology 2017;65:616-630).
SUBMITTER: Mukherjee S
PROVIDER: S-EPMC5258848 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Mukherjee Sarmistha S Chellappa Karthikeyani K Moffitt Andrea A Ndungu Joan J Dellinger Ryan W RW Davis James G JG Agarwal Beamon B Baur Joseph A JA
Hepatology (Baltimore, Md.) 20161224 2
The regenerative capacity of the liver is essential for recovery from surgical resection or injuries induced by trauma or toxins. During liver regeneration, the concentration of nicotinamide adenine dinucleotide (NAD) falls, at least in part due to metabolic competition for precursors. To test whether NAD availability restricts the rate of liver regeneration, we supplied nicotinamide riboside (NR), an NAD precursor, in the drinking water of mice subjected to partial hepatectomy. NR increased DNA ...[more]