The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells.

ABSTRACT: Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xanthophylls lutein, violaxanthin, neoxanthin, antheraxanthin and loroxanthin esters. This extract has a strong antioxidant and repairing activity in the human lung cancer cell line (A549) as shown by the increased expression of dehydrocholesterol reductase-24 (DHCR24) and prostaglandin reductase 1 (PTGR1) genes and proteins. The extract also reduces prostaglandin E₂ (PGE₂) levels in cells damaged by H₂O₂ and has tissue repairing effects on reconstructed human epidermal tissue cells (EpiDerm^TM) indicating a potential cosmeceutical activity of this microalgal species.

SUBMITTER: Sansone C 

PROVIDER: S-EPMC5259714 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature