Ontology highlight
ABSTRACT:
SUBMITTER: Lanz TV
PROVIDER: S-EPMC5259766 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Lanz Tobias V TV Williams Sarah K SK Stojic Aleksandar A Iwantscheff Simeon S Sonner Jana K JK Grabitz Carl C Becker Simon S Böhler Laura-Inés LI Mohapatra Soumya R SR Sahm Felix F Küblbeck Günter G Nakamura Toshikazu T Funakoshi Hiroshi H Opitz Christiane A CA Wick Wolfgang W Diem Ricarda R Platten Michael M
Scientific reports 20170124
The catabolism of tryptophan to immunosuppressive and neuroactive kynurenines is a key metabolic pathway regulating immune responses and neurotoxicity. The rate-limiting step is controlled by indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO). IDO is expressed in antigen presenting cells during immune reactions, hepatic TDO regulates blood homeostasis of tryptophan and neuronal TDO influences neurogenesis. While the role of IDO has been described in multiple immunological set ...[more]