A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk.
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ABSTRACT:
SUBMITTER: Elands RJ
PROVIDER: S-EPMC5259777 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk.
Elands Rachel J J RJ Simons Colinda C J M CC Riemenschneider Mona M Isaacs Aaron A Schouten Leo J LJ Verhage Bas A BA Van Steen Kristel K Godschalk Roger W L RW van den Brandt Piet A PA Stoll Monika M Weijenberg Matty P MP
Scientific reports 20170124
Data from GWAS suggest that SNPs associated with complex diseases or traits tend to co-segregate in regions of low recombination, harbouring functionally linked gene clusters. This phenomenon allows for selecting a limited number of SNPs from GWAS repositories for large-scale studies investigating shared mechanisms between diseases. For example, we were interested in shared mechanisms between adult-attained height and post-menopausal breast cancer (BC) and colorectal cancer (CRC) risk, because h ...[more]
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