Ontology highlight
ABSTRACT:
SUBMITTER: Eltoukhy AA
PROVIDER: S-EPMC5259800 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Eltoukhy Ahmed A AA Chen Delai D Veiseh Omid O Pelet Jeisa M JM Yin Hao H Dong Yizhou Y Anderson Daniel G DG
Biomaterials 20140513 24
Intracellular protein delivery has potential biotechnological and therapeutic application, but remains technically challenging. In contrast, a plethora of nucleic acid carriers have been developed, with lipid-based nanoparticles (LNPs) among the most clinically advanced reagents for oligonucleotide delivery. Here, we validate the hypothesis that oligonucleotides can serve as packaging materials to facilitate protein entrapment within and intracellular delivery by LNPs. Using two distinct model p ...[more]