Ontology highlight
ABSTRACT:
SUBMITTER: de Almagro MC
PROVIDER: S-EPMC5260504 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
de Almagro M Cristina MC Goncharov Tatiana T Izrael-Tomasevic Anita A Duttler Stefanie S Kist Matthias M Varfolomeev Eugene E Wu Xiumin X Lee Wyne P WP Murray Jeremy J Webster Joshua D JD Yu Kebing K Kirkpatrick Donald S DS Newton Kim K Vucic Domagoj D
Cell death and differentiation 20160812 1
Proper regulation of cell death signaling is crucial for the maintenance of homeostasis and prevention of disease. A caspase-independent regulated form of cell death called necroptosis is rapidly emerging as an important mediator of a number of human pathologies including inflammatory bowel disease and ischemia-reperfusion organ injury. Activation of necroptotic signaling through TNF signaling or organ injury leads to the activation of kinases receptor-interacting protein kinases 1 and 3 (RIP1 a ...[more]