Ontology highlight
ABSTRACT:
SUBMITTER: Zhang YW
PROVIDER: S-EPMC5260804 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Molecular cell 20170101 2
TET proteins, by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), are hypothesized, but not directly shown, to protect promoter CpG islands (CGIs) against abnormal DNA methylation (DNAm) in cancer. We define such a protective role linked to DNA damage from oxidative stress (OS) known to induce this abnormality. TET2 removes aberrant DNAm during OS through interacting with DNA methyltransferases (DNMTs) in a "Yin-Yang" complex targeted to chromatin and enhanced by p300 mediate ...[more]