Ontology highlight
ABSTRACT:
SUBMITTER: Huihui KM
PROVIDER: S-EPMC5260806 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Huihui Kierra M M KM Shrestha Ruja R Weix Daniel J DJ
Organic letters 20170105 2
Conjugate addition of organometallic reagents to enones to form silyl enol ether products is a versatile method to difunctionalize activated olefins, but the organometallic reagents required can be limiting. The reductive cross-electrophile coupling of unhindered primary alkyl bromides with enones and chlorosilanes to form silyl enol ether products is catalyzed by a nickel-complexed ortho-brominated terpyridine ligand. The conditions are compatible with a variety of cyclic/acyclic enones and fun ...[more]