Ontology highlight
ABSTRACT:
SUBMITTER: Mikula-Pietrasik J
PROVIDER: S-EPMC5261005 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Mikuła-Pietrasik Justyna J Uruski Paweł P Sosińska Patrycja P Maksin Konstantin K Piotrowska-Kempisty Hanna H Kucińska Małgorzata M Murias Marek M Szubert Sebastian S Woźniak Aldona A Szpurek Dariusz D Sajdak Stefan S Piwocka Katarzyna K Tykarski Andrzej A Książek Krzysztof K
Cell death & disease 20161229 12
Although both incidence and aggressiveness of ovarian malignancy rise with age, the exact reason for this tendency, in particular the contribution of senescent cells, remains elusive. In this project we found that the patient's age determines the frequency of intraperitoneal metastases of ovarian cancer. Moreover, we documented that senescent human peritoneal mesothelial cells (HPMCs) stimulate proliferation, migration and invasion of ovarian cancer cells in vitro, and that this effect is relate ...[more]